Open AccessProton pump inhibitors and adverse effects in kidney transplant recipients: A meta-analysis
Author(s) -
Boonphiphop Boonpheng,
Charat Thongprayoon,
Tarun Bathini,
Konika Sharma,
Michael A Mao,
Wisit Cheungpasitporn
Publication year - 2019
Publication title -
world journal of transplantation
Language(s) - English
Resource type - Journals
ISSN - 2220-3230
DOI - 10.5500/wjt.v9.i2.35
Subject(s) - medicine , adverse effect , meta analysis , odds ratio , hypomagnesemia , kidney disease , renal function , kidney transplantation , population , relative risk , confidence interval , transplantation , materials science , environmental health , magnesium , metallurgy
The adverse renal effects of proton pump inhibitors (PPIs) are increasingly recognized in both the general population and patients with chronic kidney disease. Several pharmacokinetic studies have also raised concerns regarding the interaction between PPIs and immunosuppressive drugs in transplant patients. Whether the adverse effects of PPIs have a clinical significance in kidney transplant recipients remains unclear. We performed this meta-analysis to assess the risk of adverse effects in kidney transplant recipients on PPI compared with those without PPI exposure.