Open AccessABO incompatibility in renal transplantation
Author(s) -
Mahmoud Mohamed,
Tara Sweeney,
Duaa Alkhader,
Mahmoud Nassar,
Ahmed Alqassieh,
Sofia Lakhdar,
Nso Nso,
Tibor Fülöp,
Ahmed Daoud,
Karim Soliman
Publication year - 2021
Publication title -
world journal of transplantation
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2220-3230
DOI - 10.5500/wjt.v11.i9.388
Subject(s) - abo blood group system , transplantation , medicine , kidney transplantation , abo incompatibility , surgery
ABO blood group incompatibility (ABO-I) was historically considered an absolute contraindication to kidney transplantation due to the significant risk of acute antibody-mediated rejection and early graft loss. Nevertheless, the urge to minimize the gap between the candidates' number on the waitlist for kidney transplants and the available kidney donors encourage investigation into finding ways to use organs from ABO-I kidney donors, especially in the era of using more potent immunosuppression therapies. This review aims to discuss a general overview of ABO-I kidney transplantation and the different protocols adopted by some transplant centers to meaningfully overcome this barrier.