Open AccessThe renin-angiotensin system, mood, and suicide: Are there associations?
Author(s) -
Marsal Sanches,
Antônio Lúcio Teixeira
Publication year - 2021
Publication title -
world journal of psychiatry
Language(s) - English
Resource type - Journals
ISSN - 2220-3206
DOI - 10.5498/wjp.v11.i9.581
Subject(s) - mood disorders , renin–angiotensin system , medicine , mood , pathophysiology , bioinformatics , association (psychology) , clinical psychology , psychiatry , psychology , psychotherapist , biology , blood pressure , anxiety
Available evidence points to a possible role of the renin-angiotensin system (RAS) in the pathophysiology of mood disorders and suicide. We carried out a critical analysis of literature data regarding this role, with a focus on the proposed association between RAS dysfunction and suicidal behavior. Epidemiological, genetic, and biochemical findings are described, and the pathophysiological hypothesis aiming at explaining the possible relationship between RAS and suicide are discussed. Available findings do support the involvement of the RAS in the neurobiology of suicide, although the exact mechanisms underlying this involvement are still unknown.