Open AccessMatrix metallopeptidases regulate granulosa cell remodeling through the hormone signaling pathway
Author(s) -
SangHwan Kim,
Jong Taek Yoon
Publication year - 2020
Publication title -
journal of advanced veterinary and animal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 9
ISSN - 2311-7710
DOI - 10.5455/javar.2020.g430
Subject(s) - luteinizing hormone , medicine , endocrinology , hormone , stimulation , zymography , follicle stimulating hormone , granulosa cell , intracellular , biology , western blot , matrix metalloproteinase , ovary , chemistry , andrology , microbiology and biotechnology , biochemistry , gene
Granulosa cells (GCs) play a very important role in reproductive physiology due to their effect on developmental and functional changes. However, there are differing views regarding the mechanism by which hormones stimulate GCs. Therefore, our study aims to determine whether GCs, in the absence of initial stimulation (17β-estradiol), select specific types of MMPs that reconstitute cells by stimulation of major hormones [follicle-stimulating hormone (FSH) or/and luteinizing hormone (LH)].