Open AccessThe impact of phosphodiesterase-5 inhibitor (sildenafil citrate) on some hippocampal neurotransmitters, oxidative stress status, minerals, and anxiety-like behavior in rats
Author(s) -
Mona H. Hafez,
Sara Elsayed El Kazaz
Publication year - 2020
Publication title -
journal of advanced veterinary and animal research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 9
ISSN - 2311-7710
DOI - 10.5455/javar.2020.g419
Subject(s) - endocrinology , medicine , chemistry , hippocampal formation , elevated plus maze , oxidative stress , neurotransmitter , anxiolytic , sildenafil , hippocampus , malondialdehyde , pharmacology , central nervous system , anxiety , receptor , psychiatry
The purpose of this work was to investigate the effect of phosphodiesterase type 5 (PDE-5) inhibitor sildenafil citrate (SC) on the level of brain hippocampal neurophysiological parameters (inhibitory and excitatory neurotransmitters), oxidant/antioxidant status, minerals, and anxiety-like behavior using albino male rats.