Open AccessNeonatal cholestasis can be the first symptom of McCune–Albright syndrome: A case report
Author(s) -
Yutaka Satomura,
Kazuhiko Bessho,
Taichi Kitaoka,
Shinji Takeyari,
Yasuhisa Ohata,
Takuo Kubota,
Keiichi Ozono
Publication year - 2021
Publication title -
world journal of clinical pediatrics
Language(s) - English
Resource type - Journals
ISSN - 2219-2808
DOI - 10.5409/wjcp.v10.i2.7
Subject(s) - mccune–albright syndrome , medicine , cholestasis , pediatrics , dermatology , precocious puberty , hormone
McCune-Albright syndrome (MAS) is caused by postzygotic somatic mutations of the GNAS gene. It is characterized by the clinical triad of fibrous dysplasia, café-au-lait skin spots, and endocrinological dysfunction. Myriad complications in MAS, including hepatobiliary manifestations, are also reported.