Open AccessThymoquinone anticancer activity is enhanced when combined with royal jelly in human breast cancer
Author(s) -
Maya M. Moubarak,
Nour Chanouha,
Najwa Abou Ibrahim,
Hala Khalife,
Hala GaliMuhtasib
Publication year - 2021
Publication title -
world journal of clinical oncology
Language(s) - English
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v12.i5.342
Subject(s) - medicine , thymoquinone , royal jelly , breast cancer , cancer , pharmacology , traditional medicine , cancer research , biochemistry , food science , chemistry , antioxidant
Breast cancer is the most common cause of the majority of cancer-related deaths in women, among which triple-negative breast cancer is the most aggressive type of breast cancer diagnosed with limited treatment options. Thymoquinone (TQ), the main bioactive constituent of Nigella sativa , has been extensively studied as a potent anticancer molecule against various types of cancers. Honeybee products such as the royal jelly (RJ), the nutritive secretion fed to honeybee queens, exhibit a variety of biological activities besides its anticancer effect. However, the anticancer activity of the combination of TQ and RJ against breast cancer is still unknown.