Open AccessRole of imaging biomarkers in mutation-driven non-small cell lung cancer
Author(s) -
Dexter P. Mendoza,
Zofia Piotrowska,
Jochen K. Lennerz,
Subba R. Digumarthy
Publication year - 2020
Publication title -
world journal of clinical oncology
Language(s) - English
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v11.i7.412
Subject(s) - medicine , lung cancer , targeted therapy , chemotherapy , mutation , oncology , cancer , personalized medicine , precision medicine , cancer research , bioinformatics , pathology , gene , biology , genetics
Lung cancer remains the leading cause of cancer-related deaths worldwide. The treatment of non-small cell lung cancer (NSCLC), which accounts for a vast majority of lung cancers, has shifted to personalized, targeted therapy following discoveries of several targetable oncogenic mutations. Targeting of specific mutations has improved outcomes in many patients. This success has led to several target-specific agents replacing chemotherapy as first-line treatment in certain mutated NSCLC. Several researchers have reported that there may be imaging biomarkers that may be predictive of the presence of these mutations. These features, when present, have the potential in triaging patients into the most appropriate diagnostic and treatment algorithms. Distinct imaging features and patterns of metastases that have been associated with NSCLC with various targetable oncogenic mutations are presented in this review.