Open AccessAberrant SOCS3 Promoter Methylation as a Noninvasive Diagnostic Biomarker for Locally Advanced Prostate Cancer
Author(s) -
Berna Demircan Tan,
Turgay Turan,
Burcu Yücel,
Sedef Altundağ Kara,
Seda Yılmaz,
Asif Yildirim
Publication year - 2020
Publication title -
medeniyet medical journal
Language(s) - English
Resource type - Journals
eISSN - 2149-2042
pISSN - 2149-4606
DOI - 10.5222/mmj.2020.58708
Subject(s) - pten , tensin , methylation , socs3 , dna methylation , epigenetics , cancer research , biomarker , prostate cancer , promoter , methyltransferase , medicine , biology , cancer , microbiology and biotechnology , oncology , gene , suppressor , gene expression , pi3k/akt/mtor pathway , genetics , signal transduction
The aim of this study was to investigate the promoter methylation status of Rasassociated domain family 1A (RASSF1A), O-6-methylguanine-DNA methyltransferase (MGMT), Phosphatase with tensin homology (PTEN) and Suppressor of cytokine signaling 3 (SOCS3) tumor suppressor genes and evaluate the clinical utility of these genes as noninvasive, blood-based epigenetic biomarkers for the diagnosis of Prostate Cancer (PCa).