Open AccessAssociation of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension
Author(s) -
Zerrin Öğretmen,
Meliha Merve Hız,
Fatma Sılan,
Ahmet Uludağ,
Ozturk Ozdemirc
Publication year - 2014
Publication title -
annals of saudi medicine/annals of saudi medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.373
H-Index - 44
eISSN - 0975-4466
pISSN - 0256-4947
DOI - 10.5144/0256-4947.2014.340
Subject(s) - medicine , psoriasis , nitric oxide synthase , endothelial nitric oxide synthase , gene polymorphism , polymorphism (computer science) , nitric oxide , gene , genotype , gastroenterology , immunology , genetics , biology , enos
Psoriasis is a common autoimmune-mediated chronic, inflammatory skin disease. Although, the molecular mechanism is not completely understood, psoriasis is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of endothelial nitric oxide synthase (eNOS Glu298Asp) gene polymorphism in hypertensive and/or non-hypertensive psoriatic patients (2) to investigate the possible relationship between the eNOS Glu298Asp polymorphism and the risk of hypertension among psoriatic patients in the Turkish population.