Open AccessInhibitory Effect of Mitoxantrone on Collagen Synthesis in Dermal Fibroblasts
Author(s) -
Kyung-Il Kim,
Chang-Il Kwon,
Jeung-Hoon Lee,
Chang Deok Kim,
TaeJin Yoon
Publication year - 2022
Publication title -
annals of dermatology/annals of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 37
eISSN - 2005-3894
pISSN - 1013-9087
DOI - 10.5021/ad.2022.34.3.206
Subject(s) - mitoxantrone , transforming growth factor , fibroblast , scars , smad , western blot , type i collagen , messenger rna , microbiology and biotechnology , medicine , chemistry , biochemistry , pathology , biology , endocrinology , in vitro , chemotherapy , gene
Fibroblasts produce collagen molecules that support the structure of the skin. The decrease and hypersynthesis of collagen causes skin problems such as skin atrophy, wrinkles and scars.