Open AccessThe Role of Collagen VI α6 Chain Gene in Atopic Dermatitis
Author(s) -
Hye Jung Jung,
Won Il Heo,
Kui Young Park,
Mi-Kyung Lee,
Jong Woong Ahn,
Mi Youn Park,
Seong Jun Seo
Publication year - 2022
Publication title -
annals of dermatology/annals of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 37
eISSN - 2005-3894
pISSN - 1013-9087
DOI - 10.5021/ad.2022.34.1.46
Subject(s) - dermis , atopic dermatitis , messenger rna , epidermis (zoology) , medicine , transfection , microbiology and biotechnology , small interfering rna , keratinocyte , mmp1 , gene expression , gene , pathology , immunology , biology , cell culture , genetics , anatomy
In a previous study, we carried out whole-exome sequencing to identify genetic variants associated with early onset atopic dermatitis (AD) in Koreans and found that collagen VI α6 chain ( COL6A6 ) gene polymorphisms are associated. COL6A6 is one of the chains that makes up the triple helix of collagen VI, and little is known about its role in AD.