Open AccessActivation of NLRP3 Inflammasome by Palmitic Acid in Human Sebocytes
Author(s) -
Yu-Ra Jung,
Jung-Hye Shin,
Chang-Hyeon Kim,
Soo-Il Kim,
Chang Deok Kim,
YoungJoon Seo,
JeungHoon Lee,
Myung Im,
Young Lee
Publication year - 2021
Publication title -
annals of dermatology/annals of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 37
eISSN - 2005-3894
pISSN - 1013-9087
DOI - 10.5021/ad.2021.33.6.541
Subject(s) - inflammasome , inflammation , medicine , secretion , caspase 1 , pathogenesis , endocrinology , interleukin , gene knockdown , in vivo , cytokine , chemistry , biochemistry , biology , apoptosis , microbiology and biotechnology
Sebocytes are the main cells involved in the pathogenesis of acne by producing lipids and inflammatory cytokines. Although palmitic acid (PA) has been suggested to induce an inflammatory reaction, its effect on sebocytes remains to be elucidated.