Frequency of Hyperprolactinemia in PCOS and its Association with Female Infertility

Introduction: Infertility is a critical health concern partially due to intricacy in its causes and striving for itsprevention, diagnosis and treatment. Various researches have documented a close linkage between polycysticovary syndrome and hyperprolactinemia. Aims & Objectives: This study was aimed to determine thefrequency of hyperprolactinemia in PCOS and its association with infertility in PCOS subjects. Place andduration of study: It was a cross sectional study, conducted during April 2017 and September 2017 at AzizFatimah Hospital, Faisalabad, Pakistan. Material & Methods: It was a cross sectional study which wasconducted at Aziz Fatimah Hospital, Faisalabad, Pakistan from April to September 2017. This studycomprised of 88 female subjects of 17-35 years old who included PCOS subjects and age matched controls.Hyperprolactinemia was assessed by the measurement of serum prolactin levels which were measured bychemiluminescence immunoassay technique (CLIA). SPSS version 22 was used for the statistical analysis ofthe data. Results: Out of total 88 female participants, 61.4% of polycystic ovary syndrome subjects hadhyperprolactinemia as compared to this 36.4% of controls had hyperprolactinemia. Pearson correlation alsorevealed significant positive association of hyperprolactinemia with infertility. Conclusion:Hyperprolactinemia was frequently seen in polycystic ovary syndrome females as well as raised BMI wasalso found. Raised prolactin levels are strongly associated with female infertility.Key words: Hyperprolactinemia, Infertilty, Polycystic Ovary Syndrome.