Open AccessThe effect of ethanol extract from Portulaca oleracea on inhibiting total cholesterol on animal subjects
Author(s) -
Afifah Bambang Sutjiatmo,
Fahmy Ahsanul Haq,
Sulaeman Al Jati,
Suci Nar Vikasari
Publication year - 2021
Publication title -
pharmacy education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.198
H-Index - 17
eISSN - 1477-2701
pISSN - 1560-2214
DOI - 10.46542/pe.2021.212.2226
Subject(s) - portulaca , simvastatin , cholesterol , body weight , ethanol , total cholesterol , zoology , medicine , traditional medicine , chemistry , pharmacology , biology , biochemistry
Hypercholesterolemia occurs when cholesterol levels in the blood increases. Traditionally, krokot (purslane, portulaca oleracea) is used to treat cardiovascular disease. Aim: This research evaluated the effect of purslane extract to inhibit increasing of cholesterol levels. Methods: The ethanol extract dosage of purslane was 27.5, 55, and 110 mg/kg body weight (bw) and simvastatin 1.8 mg/kg bw were used as comparisons. The anti-hyper cholesterol effect test was done by feeding a high cholesterol diet and drinks containing 0.01% propylthiouracil. The test parameters were body weight and total cholesterol levels on days 0, 7, 14, and 21. Results: The results showed that the extract was able to prevent the increase in body weight compared to the control group (p 0.05).