Open AccessRole of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor regulation in stress-induced pain chronification
Author(s) -
Sufang Liu,
Feng Tao
Publication year - 2017
Publication title -
world journal of biological chemistry
Language(s) - English
Resource type - Journals
ISSN - 1949-8454
DOI - 10.4331/wjbc.v8.i1.1
Subject(s) - ampa receptor , isoxazole , medicine , chronic pain , synaptic plasticity , central nervous system , sensitization , neuroplasticity , receptor , central sensitization , neuroscience , glutamate receptor , psychiatry , psychology , nociception , immunology , medicinal chemistry , chemistry
Persistent postsurgical pain is a serious issue in public health, which has received increased interest in recent years. Previous studies have reported that psychological factors promote the development of chronic postsurgical pain. However, it is unclear how chronification of postsurgical pain occurs. The α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPA) phosphorylation in the central nervous system plays a critical role in synaptic plasticity and contributes to central sensitization and chronic pain development. Here, we discuss the role of AMPA receptor regulation in stress-induced pain chronification after surgery.