Open AccessRemission is not maintained over 2 years with hematopoietic stem cell transplantation for rheumatoid arthritis: A systematic review with meta-analysis
Author(s) -
Sathish Muthu,
Madhan Jeyaraman,
Rajni Ranjan,
Saurabh Kumar Jha
Publication year - 2021
Publication title -
world journal of biological chemistry
Language(s) - English
Resource type - Journals
ISSN - 1949-8454
DOI - 10.4331/wjbc.v12.i6.114
Subject(s) - medicine , hematopoietic stem cell transplantation , rheumatoid arthritis , meta analysis , transplantation , systematic review , clinical trial , randomized controlled trial , intensive care medicine , medline , political science , law
Hematopoietic stem cell (HSC) transplantation (HSCT) is being accepted as a standard of care in various inflammatory diseases. The treatment of rheumatoid arthritis (RA) has been closely evolving with the understanding of disease pathogenesis. With the rising resistance to the traditional disease-modifying anti-rheumatic drugs and targeted biological therapy, researchers are in pursuit of other methods for disease management. Since the ultimate goal of the ideal treatment of RA is to restore immune tolerance, HSCT attracts much attention considering its reparative, paracrine, and anti-inflammatory effects. However, a systematic review of studies on HSCT in RA is lacking.