Open AccessEffects of Cyclooxygenase inhibitors on bone and cartilage metabolism: A Review
Author(s) -
C U Nwadinigwe,
U E Anyaehie
Publication year - 2008
Publication title -
nigerian journal of medicine/the nigerian journal of medicine
Language(s) - English
Resource type - Journals
eISSN - 2667-0526
pISSN - 1115-2613
DOI - 10.4314/njm.v16i4.37324
Subject(s) - cyclooxygenase , bone remodeling , medicine , bone healing , cartilage , bone resorption , prostaglandin e2 , pharmacology , enzyme , surgery , chemistry , biochemistry , anatomy
In this era of increeasing use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) for treatment of painful/inflammatory disorders, it is necessary to review the effect of these drugs on bone and cartilage metabolism. Inflammation is an essential component of the healing process in bone, and cyclooxygenase (cox-1 and cox-2) enzymes play important roles in fracture repair. Therefore, there is concern that NSAIDs, which have anti-inflammatory and analgesic properties that are mediated by inhibition of cox-1 and cox-2 may delay the healing of bone injuries. Also as newer drugs, selective cox-2 inhibitors are being developed to avert the gastrointestinal symptoms of the non-specific NSAIDs, it is imperative that these substances are studied for any deleterious effect on bone and cartilage metabolism.