Open AccessProtective effect of Livactine against CCl4 and paracetamol induced hepatotoxicity in adult Wistar rats
Author(s) -
Mayuren Candasamy,
Vudumula Varun Reddy,
Srikakulam Vishnu Priya,
Vallampatla Anusha Devi
Publication year - 2010
Publication title -
north american journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 2250-1541
pISSN - 1947-2714
DOI - 10.4297/najms.2010.2491
Subject(s) - carbon tetrachloride , medicine , toxicity , lactate dehydrogenase , alkaline phosphatase , transaminase , pharmacology , glutamate dehydrogenase , alanine transaminase , jaundice , aspartate transaminase , liver disease , bilirubin , population , liver injury , enzyme , biochemistry , chemistry , glutamate receptor , receptor , environmental health , organic chemistry
Liver disease has become one of the serious health problems as it is exposed to many kinds of xenobiotics and therapeutic agents. Moreover the rapidly growing morbidity and mortality from liver disease are attributable to the increasing number of chemical compounds and environmental pollution. Unfortunately, so far, in the modern era of medicine there is no specific treatment to counter the menacing impact of these dreaded diseases. Many polyherbal formulations are used widely to treat these disorders. Livactine is a polyherbal formulation and is claimed to be useful in jaundice and biliary dysfunctions. Most of these formulations do not have standard and approved reports stating their pharmacological action or therapeutic efficacy. Therefore, there is a need for experimental confirmation of the pharmacological effects of this formulation. The rationale behind the selection of carbon tetrachloride is due to its free radical mechanism based liver injury, and paracetamol is consumed widely by the human population and it is also a potential liver hazard.