Open AccessDifferential diagnosis in ulcerative colitis in an adolescent: Chronic granulomatous disease needs extra attention
Author(s) -
Daniel Kotlarz,
Ödül Eğritaş Gürkan,
Zehra Şule Haskoloğlu,
Özgür Ekinci,
Aysel Ünlüsoy,
Neslihan Gürcan Kaya,
Jaçek Puchalka,
Cristoph Klein,
Buket Dalgıç
Publication year - 2017
Publication title -
world journal of gastrointestinal pathophysiology
Language(s) - English
Resource type - Journals
ISSN - 2150-5330
DOI - 10.4291/wjgp.v8.i2.87
Subject(s) - medicine , ulcerative colitis , chronic granulomatous disease , inflammatory bowel disease , differential diagnosis , colectomy , disease , immune system , total colectomy , granuloma , immune dysregulation , immunology , dermatology , pathology
Chronic granulomatous disease (CGD) is a primary immune deficiency that is commonly diagnosed under the age of 5 years (95%) and is rarely seen in adulthood. CGD may manifest as inflammatory bowel disease (IBD) in childhood. Without proper diagnosis, these patients may be monitored for years as IBD; some may even be regarded as steroid-resistant ulcerative colitis (UC) and end up having a colectomy. In this case report, we described a patient who had been followed-up for years as UC and subsequently underwent colectomy, but was finally diagnosed in adulthood as primary immune deficiency.