Open AccessEvaluating the regulation of transporter proteins and P-glycoprotein in rats with cholestasis and its implication for digoxin clearance
Author(s) -
Parker Giroux,
Patrick B. Kyle,
Chalet Tan,
Joseph Edwards,
Michaeł Nowicki,
Hua Liu
Publication year - 2022
Publication title -
world journal of gastrointestinal pathophysiology
Language(s) - English
Resource type - Journals
ISSN - 2150-5330
DOI - 10.4291/wjgp.v13.i3.73
Subject(s) - digoxin , cholestasis , medicine , p glycoprotein , kidney , endocrinology , transporter , probenecid , renal function , organic anion transporter 1 , multidrug resistance associated protein 2 , pharmacology , atp binding cassette transporter , multiple drug resistance , biology , biochemistry , heart failure , gene , antibiotics
Cardiac and hepatic functionality are intertwined in a multifaceted relationship. Pathologic processes involving one may affect the other through a variety of mechanisms, including hemodynamic and membrane transport effects.