Open AccessInfluence of anastomoses on intestine ischemia and cefuroxime concentrations: Evaluated in the ileum and colon in a porcine model
Author(s) -
Pelle Hanberg,
Mats Bue,
Maja Thomassen,
Uffe S. Løve,
Josephine Olsen Kipp,
Christina Harlev,
Elisabeth Petersen,
Kjeld Søballé,
Maiken Stilling
Publication year - 2021
Publication title -
world journal of gastrointestinal pathophysiology
Language(s) - English
Resource type - Journals
ISSN - 2150-5330
DOI - 10.4291/wjgp.v12.i1.1
Subject(s) - medicine , ileum , anastomosis , large intestine , ischemia , intestinal ischemia , gastroenterology , surgery , reperfusion injury
Anastomotic leakage is a serious complication following gastrointestinal surgery and is associated with increased morbidity and mortality. The incidence of anastomotic leakage is determined by anatomy and is reported to be between 4%-33% for colon anastomosis and 1%-3% for small intestine anastomosis. The etiology of anastomotic leakage of the intestine has been divided into three main factors: healing disturbances, communication between intra- and extra-luminal compartments, and infection. All three factors interact, and one factor will inevitably lead to the other two factors resulting in tissue ischemia, tissue necrosis, and anastomotic leakage.