Open AccessPilot Algorithm Designed to Help Early Detection of HMG-CoA Reductase Inhibitor-Induced Hepatotoxicity
Author(s) -
Joo Young Hong,
Hun-Sung Kim,
In Young Choi
Publication year - 2017
Publication title -
healthcare informatics research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 29
eISSN - 2093-369X
pISSN - 2093-3681
DOI - 10.4258/hir.2017.23.3.199
Subject(s) - algorithm , medicine , statin , medical prescription , confidence interval , concomitant , alanine transaminase , aspartate transaminase , adverse effect , alkaline phosphatase , pharmacology , computer science , biochemistry , chemistry , enzyme
To enable early detection of adverse drug reactions (ADRs) in patients using HMG-CoA reductase inhibitors (statins), we developed an algorithm that automatically detects liver injury caused by statins from Electronic Medical Record (EMR) data. We verified the performance of our algorithm through manual ADR assessment and a direct chart review.