Open AccessRole of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4-/-mouse model
Author(s) -
Florian P. Reiter,
Ralf Wimmer,
Lena Wottke,
Renate Artmann,
J. Nagel,
Manuel O Carranza,
Doris Mayr,
Christian Rust,
Peter Fickert,
Michael Trauner,
Alexander L. Gerbes,
Simon Hohenester,
Gerald Denk
Publication year - 2016
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v8.i8.401
Subject(s) - sirius red , hepatic stellate cell , hydroxyproline , timp1 , cholestasis , fibrosis , in vivo , medicine , liver injury , hepatic fibrosis , endocrinology , microbiology and biotechnology , andrology , biology , biochemistry , gene expression , gene
To study the interleukin-1 (IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4(-/-) (Abcb4(-/-)) mouse model.