Open AccessChemokines and their receptors play important roles in the development of hepatocellular carcinoma
Author(s) -
Chao Liang,
Guolin Chen,
Heng Hu,
Heng Ma,
Lingling Gao,
Jie Qin,
Cuiping Zhong
Publication year - 2015
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v7.i10.1390
Subject(s) - chemokine , hepatocellular carcinoma , chemokine receptor , medicine , ccr10 , angiogenesis , immune system , cxc chemokine receptors , receptor , immunology , inflammation , cancer research
The chemokine system consists of four different subclasses with over 50 chemokines and 19 receptors. Their functions in the immune system have been well elucidated and research during the last decades unveils their new roles in hepatocellular carcinoma (HCC). The chemokines and their receptors in the microenvironment influence the development of HCC by several aspects including: inflammation, effects on immune cells, angiogenesis, and direct effects on HCC cells. Regarding these aspects, pre-clinical research by targeting the chemokine system has yielded promising data, and these findings bring us new clues in the chemokine-based therapies for HCC.