Open AccessPentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion
Author(s) -
Marijan Kolovrat,
Slaven Gojković,
Ivan Krezić,
Dominik Malekinušić,
Borna Vrdoljak,
Katarina Kasnik Kovac,
Tamara Kralj,
Domagoj Drmić,
Ivan Barišić,
Katarina Horvat Pavlov,
Andreja Petrović,
Antonija Đuzel,
Martina Knežević,
Ivan Mirković,
Antonio Kokot,
Alenka Boban Blagaić,
Sven Seiwerth,
Predrag Sikirić
Publication year - 2020
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v12.i5.184
Subject(s) - medicine , ischemia , anesthesia , inferior mesenteric vein , superior mesenteric vein , occlusion , cirrhosis , cardiology , portal hypertension , thrombosis , portal venous pressure , portal vein
The Pringle maneuver [portal triad obstruction(PTO)] provides huge disturbances during ischemia and even more thereafter in reperfusion. Contrarily, a possible solution may be stable gastric pentadecapeptide BPC 157, with already documented beneficial effects in ischemia/reperfusion conditions. Recently, BPC 157, as a cytoprotective agent, successfully resolved vessel occlusions in rats (ischemic colitis; deep vein thrombosis, superior anterior pancreaticoduodenal vein; bile duct cirrhosis) through rapid collateral vessel recruitment to circumvent vessel occlusion. Thereby, medication BPC 157 regimens were administered as a single challenge before and during ischemia or, alternatively, at various time points during reperfusion.