Open AccessmiR-3682-3p directly targets FOXO3 and stimulates tumor stemness in hepatocellular carcinoma via a positive feedback loop involving FOXO3/PI3K/AKT/c-Myc
Author(s) -
Qian Chen,
Sibo Yang,
Yewei Zhang,
Sang Mi Han,
Lei Jia,
Bo Li,
Yi Zhang,
Shi Zuo
Publication year - 2022
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v14.i7.539
Subject(s) - cancer research , protein kinase b , pi3k/akt/mtor pathway , downregulation and upregulation , hepatocellular carcinoma , medicine , chemistry , biology , microbiology and biotechnology , signal transduction , biochemistry , gene
Cancer stem cells (CSCs) have been implicated in tumorigenesis and tumor recurrence and metastasis are key therapeutic targets in cancer treatment. MicroRNAs display therapeutic potential by controlling the properties of CSCs; however, whether an association exists between miR-3682-3p and CSCs is unknown.