Open AccessTranscriptomic alterations underline aging of osteogenic bone marrow stromal cells
Author(s) -
Yu Cheng,
Shu Fen Liu,
Jing Dong,
Qin Bian
Publication year - 2021
Publication title -
world journal of stem cells
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v13.i1.128
Subject(s) - stromal cell , bone marrow , transcriptome , microbiology and biotechnology , medicine , cancer research , biology , pathology , gene , biochemistry , gene expression
Multipotent bone marrow stromal cells (BMSCs) are adult stem cells that form functional osteoblasts and play a critical role in bone remodeling. During aging, an increase in bone loss and reduction in structural integrity lead to osteoporosis and result in an increased risk of fracture. We examined age-dependent histological changes in murine vertebrae and uncovered that bone loss begins as early as the age of 1 mo.