Open AccessMesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles: Potential roles in rheumatic diseases
Author(s) -
Jinghan Yang,
Fengxia Liu,
Jinghua Wang,
Min Cheng,
Shufeng Wang,
Dongmei Xu
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i7.688
Subject(s) - mesenchymal stem cell , medicine , rheumatoid arthritis , osteoarthritis , regenerative medicine , immune system , stem cell , regeneration (biology) , disease , immunogenicity , immunology , arthritis , bioinformatics , pathology , biology , microbiology and biotechnology , alternative medicine
Mesenchymal stem cells (MSCs) have been widely investigated in rheumatic disease due to their immunomodulatory and regenerative properties. Recently, mounting studies have implicated the therapeutic potency of MSCs mostly due to the bioactive factors they produce. Extracellular vesicles (EVs) derived from MSCs have been identified as a promising cell-free therapy due to low immunogenicity. Rheumatic disease, primarily including rheumatoid arthritis and osteoarthritis, is a group of diseases in which immune dysregulation and chronic progressive inflammation lead to irreversible joint damage. Targeting MSCs and MSC-derived EVs may be a more effective and promising therapeutic strategy for rheumatic diseases.