Open AccessRole of stem cell therapies in treating chronic wounds: A systematic review
Author(s) -
Anjali C. Raghuram,
Roy P. Yu,
Andrea Y. Lo,
Cynthia Sung,
Melissa Bircan,
Holly Thompson,
Alex K. Wong
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i7.659
Subject(s) - medicine , stem cell , mesenchymal stem cell , stem cell therapy , wound healing , regeneration (biology) , bioinformatics , pathology , surgery , biology , genetics , microbiology and biotechnology
The impairment of cutaneous wound healing results in chronic, non-healing wounds that are caused by altered wound environment oxygenation, tissue injury, and permissive microbial growth. Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis. Consequently, stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.