Open AccessApproaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface
Author(s) -
Shicheng Huo,
Bing Yue
Publication year - 2020
Publication title -
world journal of stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 18
ISSN - 1948-0210
DOI - 10.4252/wjsc.v12.i7.545
Subject(s) - osseointegration , mesenchymal stem cell , regenerative medicine , stem cell , implant , biomedical engineering , medicine , orthopedic surgery , bone marrow , dentistry , pathology , microbiology and biotechnology , surgery , biology
Bone marrow-derived mesenchymal stem cells (BMSCs) play a critical role in the osseointegration of bone and orthopedic implant. However, osseointegration between the Ti-based implants and the surrounding bone tissue must be improved due to titanium's inherent defects. Surface modification stands out as a versatile technique to create instructive biomaterials that can actively direct stem cell fate. Here, we summarize the current approaches to promoting BMSC osteogenesis on the surface of titanium and its alloys. We will highlight the utilization of the unique properties of titanium and its alloys in promoting tissue regeneration, and discuss recent advances in understanding their role in regenerative medicine. We aim to provide a systematic and comprehensive review of approaches to promoting BMSC osteogenesis on the orthopedic implant surface.