Open AccessImmune cell interplay in colorectal cancer prognosis
Author(s) -
Samuel E Norton,
Kirsten A. WardHartstonge,
E. S. Taylor,
Roslyn A. Kemp
Publication year - 2015
Publication title -
world journal of gastrointestinal oncology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v7.i10.221
Subject(s) - immune system , medicine , colorectal cancer , acquired immune system , disease , immunology , population , cancer , cancer research , pathology , environmental health
The immune response to colorectal cancer has proven to be a reliable measure of patient outcome in several studies. However, the complexity of the immune response in this disease is not well understood, particularly the interactions between tumour-associated cells and cells of the innate and adaptive immune system. This review will discuss the relationship between cancer associated fibroblasts and macrophages, as well as between macrophages and T cells, and demonstrate how each population may support or prevent tumour growth in a different immune environment.