Open AccessAssociation and prognostic significance of alpha-L-fucosidase-1 and matrix metalloproteinase 9 expression in esophageal squamous cell carcinoma
Author(s) -
Xiangyang Yu,
Shengcheng Lin,
Mengqi Zhang,
Xiaotong Guo,
Kai Ma,
Lixu Wang,
Wenting Huang,
Zhe Wang,
Yu Xin,
Chunguang Wang,
Lanjun Zhang,
Zhentao Yu
Publication year - 2022
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v14.i2.498
Subject(s) - medicine , immunohistochemistry , lymphovascular invasion , stage (stratigraphy) , esophagectomy , adenocarcinoma , esophageal cancer , oncology , matrix metalloproteinase , metastasis , cancer , pathology , cancer research , biology , paleontology
Alpha-L-fucosidase-1 (FUCA1) has been demonstrated to play opposing regulatory roles in adenocarcinoma and non-adenocarcinoma. Moreover, recent studies reported that FUCA1 could decrease the invasion capability by downregulating matrix metalloproteinase 9 (MMP-9) expression. However, the potential role and prognostic significance of FUCA1 in esophageal squamous cell carcinoma (ESCC) have not yet been explored.