Open AccessCryptotanshinone inhibits cytotoxin-associated gene A-associated development of gastric cancer and mucosal erosions
Author(s) -
Zhangming Chen,
Jie Hu,
Yihang Xu,
Weichun He,
Lei Meng,
Ting Huang,
Ying Shi,
Zhe Jiang,
Aman Xu
Publication year - 2021
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v13.i7.693
Subject(s) - medicine , cancer , gene , cancer research , genetics , biology
Approximately 90% of new cases of noncardiac gastric cancer (GC) are related to Helicobacter pylori (H. pylori) , and cytotoxin-associated gene A (CagA) is one of the main pathogenic factors. Recent studies have shown that the pharmacological effects of cryptotanshinone (CTS) can be used to treat a variety of tumors. However, the effects of CTS on H. pylori , especially CagA+ strain-induced gastric mucosal lesions, on the development of GC is unknown.