Open AccessChanges in extracellular matrix in different stages of colorectal cancer and their effects on proliferation of cancer cells
Author(s) -
Zhu-Lin Li,
Zhenjun Wang,
Guanghui Wei,
Yong Yang,
Xiaowan Wang
Publication year - 2020
Publication title -
world journal of gastrointestinal oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 26
ISSN - 1948-5204
DOI - 10.4251/wjgo.v12.i3.267
Subject(s) - colorectal cancer , extracellular matrix , cancer , cancer research , medicine , cancer cell , carcinogenesis , mouse model of colorectal and intestinal cancer , matrix metalloproteinase , pathology , biology , microbiology and biotechnology
The extracellular matrix is the main component of the tumor microenvironment. Extracellular matrix remodels with the oncogenesis and development of tumors. Previous studies usually focused on the changes of proteins in normal colorectal tissues and colorectal cancers. Little is known about the changes in the extracellular matrix in different stages of colorectal cancer and the effects of these changes on the development of this cancer.