Open AccessHigh fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: Role of endoplasmic-reticulum-stress
Author(s) -
Maha Coucha,
Islam Mohamed,
Sally L. Elshaer,
Osinakachuk Mbata,
Megan L. Bartasis,
Azza B. El-Remessy
Publication year - 2017
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v8.i2.56
Subject(s) - endoplasmic reticulum , unfolded protein response , endocrinology , medicine , thioredoxin , biology , downregulation and upregulation , microbiology and biotechnology , biochemistry , oxidative stress , gene
To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation.