Open AccessInvestigating the specificity of endothelin-traps as a potential therapeutic tool for endothelin-1 related disorders
Author(s) -
Arjun Jain,
Krištof Bozovičar,
Vidhi Mehrotra,
Tomaž Bratkovič,
Martin H. Johnson,
Ira Jha
Publication year - 2022
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v13.i6.434
Subject(s) - medicine , endothelin receptor , endothelin 1 , receptor , computational biology , bioinformatics , biology
Endothelin (ET)-traps are Fc-fusion proteins with a design based on the physiological receptors of ET-1. Previous work has shown that use of the selected ET-traps potently and significantly reduces different markers of diabetes pathology back to normal, non-disease levels.