Open AccessPolymorphisms in HIF-1a gene are not associated with diabetic retinopathy in China
Author(s) -
Yuehong Liu,
Chang Guo,
Yi-Qiong Sun,
Qiang Li
Publication year - 2021
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v12.i8.1304
Subject(s) - medicine , diabetic retinopathy , diabetes mellitus , gene , bioinformatics , ophthalmology , genetics , endocrinology , biology
It has been reported that vascular endothelial growth factor (VEGF) is a susceptibility gene for both type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR). In response to hypoxia, VEGF mRNA levels are increased, which is mainly mediated by the binding of hypoxia-inducible factor-1 (HIF-1) and hypoxia response element upstream of the transcriptional start site of VEGF. Therefore, HIF-1a is supposed to be involved in pathology of DR.