Open AccessBlood glucose response after oral lactulose intake in type 2 diabetic individuals
Author(s) -
Thomas R. Pieber,
Eva Švehlíková,
Ines Mursic,
Tamara Esterl,
Manfred Wargenau,
Tina Sartorius,
Lioba Pauly,
Susann Schwejda-Guettes,
Annaleeumann,
Valentin Faerber,
John Stover,
Barbara Gaigg,
Angelika Kuchinka-Koch
Publication year - 2021
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v12.i6.893
Subject(s) - medicine , diabetes mellitus , lactulose , type 2 diabetes , physiology , endocrinology
Lactulose is approved for the symptomatic treatment of constipation, a gastrointestinal (GI) complication common in individuals with diabetes. Lactulose products contain carbohydrate impurities ( e.g., lactose, fructose, galactose), which occur during the lactulose manufacturing process. These impurities may affect the blood glucose levels of individuals with type 2 diabetes mellitus (T2DM) using lactulose for the treatment of mild constipation. A previous study in healthy subjects revealed no increase in blood glucose levels after oral lactulose intake. However, it is still unclear whether the intake of lactulose increases blood glucose levels in individuals with diabetes.