Open AccessRelationship between serum Dickkopf-1 and albuminuria in patients with type 2 diabetes
Author(s) -
Ningning Hou,
Chengxia Kan,
Na Huang,
Yongping Liu,
En-Wen Mao,
Yuting Ma,
Fang Han,
Haijie Sun,
Xiaodong Sun
Publication year - 2021
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v12.i1.47
Subject(s) - albuminuria , microalbuminuria , medicine , endocrinology , diabetes mellitus , creatinine , type 2 diabetes , renal function , kidney disease , diabetic nephropathy
Diabetic kidney disease is a microvascular complication of diabetes with complex pathogenesis. Wingless signaling-mediated renal fibrosis is associated with diabetic kidney disease. Dickkopf-1, a negative regulator of Wingless, has been proven to participate in renal fibrosis, glucose metabolism, and inflammation. However, whether serum Dickkopf-1 levels are associated with diabetic kidney disease remains unclear.