Open AccessMetformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop
Author(s) -
Yang Zhou,
Xiaoyu Ma,
Jinyu Han,
Min Yang,
Chuan Lv,
Ying Shao,
Yili Wang,
Jia-Yi Kang,
Qiuyue Wang
Publication year - 2021
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v12.i1.19
Subject(s) - medicine , metformin , inflammation , fibrosis , tlr4 , diabetes mellitus , nf κb , kidney disease , disease , inflammatory response , immunology , endocrinology
Type 2 diabetes mellitus (T2DM) is significantly increasing worldwide, and the incidence of its complications is also on the rise. One of the main complications of T2DM is diabetic kidney disease (DKD). The glomerular filtration rate (GFR) and urinary albumin creatinine ratio (UACR) increase in the early stage. As the disease progresses, UACR continue to rise and GFR begins to decline until end-stage renal disease appears. At the same time, DKD will also increase the incidence and mortality of cardiovascular and cerebrovascular diseases. At present, the pathogenesis of DKD is not very clear. Therefore, exploration of the pathogenesis of DKD to find a treatment approach, so as to delay the development of DKD, is essential to improve the prognosis of DKD.