Open AccessAnalysis of long noncoding RNA-associated competing endogenous RNA network in glucagon-like peptide-1 receptor agonist-mediated protection in β cells
Author(s) -
Lijuan Cui,
Tao Bai,
Linping Zhi,
Zhihong Liu,
Tao Liu,
Xue Hai,
Huanhuan Yang,
Xiaohua Yang,
Min Zhang,
Ya-Ru Niu,
Yunfeng Liu,
Yi Zhang
Publication year - 2020
Publication title -
world journal of diabetes
Language(s) - English
Resource type - Journals
ISSN - 1948-9358
DOI - 10.4239/wjd.v11.i9.374
Subject(s) - kegg , competing endogenous rna , biology , long non coding rna , signal transduction , rna , microbiology and biotechnology , computational biology , gene expression , gene , genetics , gene ontology
Long noncoding RNAs (lncRNAs) and mRNAs are widely involved in various physiological and pathological processes. The use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) is a novel therapeutic strategy that could promote insulin secretion and decrease the rate of β-cell apoptosis in type 2 diabetes mellitus (T2DM) patients. However, the specific lncRNAs and mRNAs and their functions in these processes have not been fully identified and elucidated.