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In August 2015, FDA published a black box declaring that DPP-4 inhibitors may cause severe joint pains. The impact on autoimmunity marker positivity of these drugs has not been comprehensively evaluated. We compared the incidence of arthritis/arthralgia in patients with T2DM who were using DPP-4 inhibitors and patients who were not using.

DPP-4 Inhibitors Increase the Incidence of Arthritis/Arthralgia but do Not Affect Autoimmunity