Open AccessCirculating microRNAs as biomarkers in bile-derived exosomes of cholangiocarcinoma
Author(s) -
Jin-Yi Han,
Keun Soo Ahn,
Yong Hoon Kim,
TaeSeok Kim,
Won-Ki Baek,
Seong-Il Suh,
Koo Jeong Kang
Publication year - 2021
Publication title -
annals of surgical treatment and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.559
H-Index - 25
eISSN - 2288-6796
pISSN - 2288-6575
DOI - 10.4174/astr.2021.101.3.140
Subject(s) - microrna , microvesicles , biology , messenger rna , mapk/erk pathway , pi3k/akt/mtor pathway , cancer research , protein kinase b , signal transduction , gene , microbiology and biotechnology , genetics
In this pilot study, using next-generation sequencing and integrated messenger RNA (mRNA) sequencing, we investigated circulating microRNA (miRNA) expression profiling from bile-derived exosomes to identify dysregulated miRNA signatures and oncogenic pathways and determine their effects on targeted mRNAs in cholangiocarcinoma (CCA). Moreover, we explored the possibility that genetic analysis using bile-derived exosomes may replace gene analysis using tissue.