Open AccessTET2 Regulates 5-Hydroxymethylcytosine Signature and CD4+ T-Cell Balance in Allergic Rhinitis
Author(s) -
Lu Tan,
Lisheng Fu,
Lirong Zheng,
Wenjun Fan,
Hanyu Tan,
Zezhang Tao,
Yu Xu
Publication year - 2022
Publication title -
allergy, asthma and immunology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 45
eISSN - 2092-7363
pISSN - 2092-7355
DOI - 10.4168/aair.2022.14.2.254
Subject(s) - allergic inflammation , ovalbumin , inflammation , immunology , t cell , microbiology and biotechnology , chemistry , biology , immune system
Previous studies have shown the role of ten-eleven translocation 2 (TET2) in CD4 + T cells. However, its function in CD4 + T cells under allergic inflammation is unclear. We aimed to investigate the epigenomic distribution of DNA 5-hydroxymethylcytosine (5hmC) and the role of TET2 in CD4 + T cells of allergic rhinitis (AR).