Open AccessProtective effects of Populus tomentiglandulosa against cognitive impairment by regulating oxidative stress in an amyloid beta25–35-induced Alzheimer's disease mouse model
Author(s) -
Yuri Kwon,
Jihyun Kim,
SangHyun Lee,
Ho Kim,
Eun Ju Cho
Publication year - 2022
Publication title -
nutrition research and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.506
H-Index - 34
eISSN - 2005-6168
pISSN - 1976-1457
DOI - 10.4162/nrp.2022.16.2.173
Subject(s) - oxidative stress , morris water navigation task , amyloid beta , reactive oxygen species , lipid peroxide , antioxidant , cognitive deficit , nitric oxide , pharmacology , medicine , chemistry , endocrinology , biochemistry , cognitive impairment , disease , lipid peroxidation , hippocampus
Alzheimer's disease (AD) is one of the most representative neurodegenerative disease mainly caused by the excessive production of amyloid beta (Aβ). Several studies on the antioxidant activity and protective effects of Populus tomentiglandulosa (PT) against cerebral ischemia-induced neuronal damage have been reported. Based on this background, the present study investigated the protective effects of PT against cognitive impairment in AD.