Open Accessβ-carotene regulates cancer stemness in colon cancer in vivo and in vitro
Author(s) -
Kyung Eun Lee,
Minseo Kwon,
Yoo Sun Kim,
Yerin Kim,
Min Gi Chung,
Seung Chul Heo,
Yuri Kim
Publication year - 2022
Publication title -
nutrition research and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.506
H-Index - 34
eISSN - 2005-6168
pISSN - 1976-1457
DOI - 10.4162/nrp.2022.16.2.161
Subject(s) - cd44 , cancer stem cell , wnt signaling pathway , sox2 , clonogenic assay , colorectal cancer , cancer research , stem cell , cancer , in vivo , cancer cell , in vitro , medicine , biology , signal transduction , microbiology and biotechnology , biochemistry , transcription factor , gene
Colorectal cancer (CRC) is the third most common cancer worldwide and has a high recurrence rate, which is associated with cancer stem cells (CSCs). β-carotene (BC) possesses antioxidant activity and several anticancer mechanisms. However, no investigation has examined its effect on colon cancer stemness.