Open AccessActivation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ
Author(s) -
Jing Zhou,
Zhanzhao Liu,
LingJing Zhang,
Xiao Hu,
Zhihua Wang,
Ní Hóng,
Yue Wang,
Jianjie Qin
Publication year - 2020
Publication title -
cancer research and treatment/cancer research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.668
H-Index - 40
eISSN - 2005-9256
pISSN - 1598-2998
DOI - 10.4143/crt.2019.510
Subject(s) - angiogenesis , chronic stress , medicine , endocrinology , peroxisome proliferator activated receptor , breast cancer , receptor , cancer research , vascular endothelial growth factor , agonist , cancer , vegf receptors
Chronic stress and related hormones are key in cancer progression. Peroxisome proliferator-activated receptor γ (PPARγ) and its agonists was reported that inducing anti-tumor effect. However, the function of PPARγ in pro-tumorigenic effects induced by chronic stress in breast cancer remains unknown. Herein, we have characterized a novel role of PPARγ and vascular endothelial growth factor (VEGF)/fibroblast growth factor 2 (FGF2) signals in breast cancer promoted by chronic stress.