Open AccessSRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
Author(s) -
Jung Taek Kang,
Hyung Jin Kim,
Hyun Ju Oh,
So Gun Hong,
Jung Eun Park,
Min Jung Kim,
Min Kyu Kim,
Goo Jang,
Dae Yong Kim,
Byeong Chun Lee
Publication year - 2012
Publication title -
journal of veterinary science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.547
H-Index - 47
eISSN - 1976-555X
pISSN - 1229-845X
DOI - 10.4142/jvs.2012.13.2.211
Subject(s) - testis determining factor , ovotestis , biology , karyotype , genetics , true hermaphroditism , y chromosome , germline mosaicism , gene , somatic cell , anatomy , gonad , chromosome
Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but developed ovotestis. Through molecular analysis of the SRY gene, a mutation in the coding sequence of SRY gene could be excluded as a cause of intersexuality. This is the first report of a cloned wolf with a 78, XY ovotesticular disorder affecting sexual development characterized by bilateral ovotestes.