Open AccessSarcomatoid urothelial carcinoma arising in the female urethral diverticulum
Author(s) -
Heae Surng Park
Publication year - 2021
Publication title -
journal of pathology and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 27
eISSN - 2383-7845
pISSN - 2383-7837
DOI - 10.4132/jptm.2021.04.23
Subject(s) - medicine , dysuria , sarcomatoid carcinoma , diverticulum (mollusc) , urethral diverticulum , urothelium , carcinoma , pathology , vagina , urinary bladder , cystoscopy , urology , urethra , urinary system , anatomy , alternative medicine
A sarcomatoid variant of urothelial carcinoma in the female urethral diverticulum has not been reported previously. A 66-year-old woman suffering from dysuria presented with a huge urethral mass invading the urinary bladder and vagina. Histopathological examination of the resected specimen revealed predominantly undifferentiated pleomorphic sarcoma with sclerosis. Only a small portion of conventional urothelial carcinoma was identified around the urethral diverticulum, which contained glandular epithelium and villous adenoma. The patient showed rapid systemic recurrence and resistance to immune checkpoint inhibitor therapy despite high expression of programmed cell death ligand-1. We report the first case of urethral diverticular carcinoma with sarcomatoid features.